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Phil Andrews Research Group
Educational qualifications
- B.Sc (Honours)in Chemistry – Delhi University, New Delhi, India
- Masters in Chemistry (Specialising in Inorganic Chemistry) – Indian Institute of Technology (Roorkee), India .
Research Areas
Title of the current project : Synthesis, characterization and testing of non-ionic, non-iodinated, water soluble metal cluster compounds for MRI and CT scanning.
Summary: This project aims to develop (synthesis, characterization and testing) non-iodinated, non-ionic, water soluble contrast media, replacing iodine with metal based compounds of low toxicity. The targets will be metal-organic bismuth clusters which have oxide clusters at their core but which are designed to have a hydrophilic outer surface which allows them to be water soluble and kinetically inert for a suitable period of time in physiological environments to achieve an X-ray generated image. The high metal concentration in the oxide core will provide greater X-ray opacity and contrast at a significantly lower dose level than those presently used for iodinated compounds with concomitant lower radiation exposure for the patient. Our approach is to form polynuclear clusters that are sheathed in appropriate organic groups that effect high aqueous solubility and also deliver high kinetic and thermodynamic stability for example bismuth carboxylates and bismuth alkoxides. This will be achieved by use of highly polar, non-ionic groups tethered to aryl carboxylic acid as well as amino acids.
Project carried out previously: Synthesis and characterisation of polymer anchored complexes.
Summary: A series of chloromethylated polystyrene anchored metal complexes were prepared by the reaction of metal/salt complex with polymer anchored ligands such as 2- a- hydroxymethylbenzimidazole and 2-a-hydroxyethylbenzimidazole.Then these polymer anchored metal complexes were characterized by Electronic spectra, Infra Red spectra and Thermogravimetric analysis. Catalytic activity of these polymer anchored metal complexes were also studied using oxidative bromination of salicylaldehyde.
Conferences Attended
- Seminar organized as a part of National symposium “INDIAN COUNCIL OF CHEMISTS” held at IIT ROORKEE from Oct17 to Oct 19-2003
- Australian Organometallic conference , “OZOM3-2006” at Monash University –Gippsland campus from 8 Jan to 11 Jan -2006. Oral presentation: “ Synthesis of Bismuth Carboxylates”
- 37TH International Conference of Coordination Chemistry, 13/08/2006-18/08/2006, Cape Town, South Africa. Poster presentation: "Structural and Synthetic Comparisons of Bi (III) CArboxylates".
Publications
- "Synthetic and Structural Comparisons of Bismuth(III) Carboxylates Synthesised under Solvent-free and Reflux Condition”,Philip.C. Andrews, Glen. B. Deacon, Peter C. Junk, Ish Kumar and Morry Silberstein, Dalton Transactions, Aceepted
- “Towards a structural understanding of the Anti-Ulcer and Anti-Gastritis Drug, Bismuth Subsalicylate(BSS)”, Philip.C.Andrews, Glen. B. Deacon, Craig M. Forsyth Peter C. Junk, Ish Kumar and
Melissa Maguire, Angew. Chem. Int. Ed. Engl, Volume 45, Issue 34, 2006, 5638-5642.
Achievements
- Cleared Council of Scientific and Industrial Research (CSIR) Lecturership Examination (University grants Commission, India)
Work Experience
As a teacher trainee taught Chemistry to Grades 11th and 12th from July 2004 to February 2005.
Teaching commitments
- CHM 1031: World of Chemistry 1-Practicals
- CHM 1070: Basic chemistry for Engineers-Practicals.
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