Phil Andrews Research Group
Educational qualifications
- Bachelor of Arts (Indonesian)
- Bachelor of Science (Chemistry/Pharmacology)
- Honours Degree of Bachelor of Science
Research Areas
Title of the current project : Synthesis, characterisation and application of newl homo- and hereto- bimetallic chiral metal amides and phosphites.
Honours Project: Chiral alkali metal amides and their use in asymmetric conjugate addition.
Summary: Chiral metal amides are now established among the most important reagents and intermediates in asymmetric synthesis, most recently the use of the lithium complexes in the formation of new biologically active ?-amino acids and ?-lactams.
The project involved the first synthesis and characterisation of a monolithiated (S) N (a-methylbenzyl)allylamine complex, {(S) a (PhC(H)CH3NCH2CH=CH2)Li.HMPA}2. Attempted synthesis of dilithiated (S) N (a-methylbenzyl)allylamine in the presence of HMPA resulted in the isolation and characterisation of lithium diamidophosphite, {(Me2N)2POLi}6,which was structurally authenticated for the first time.
The synthesis and characterisation of two (R,R)-(+)-bis-(a-methylbenzyl)amine complexes is also reported, including {(R,R)-a-(PhC(H)CH3)2N)Li.HMPA}2 and {(R,R) a (PhC(H)CH3)2N)Li.dioxane}2.
The comparative study between lithium and sodium resulted in the synthesis and characterisation of t-butyl (2S,3S,aS)3 (allyl 1 phenylethyl)amino) 2 fluoro 3 phenylpropanoate from the lithiated derivative. The reaction using the sodium derivative resulted in the isolation and characterisation of unexpected addition products, with their identity not completely authenticated.
Achievements
- Dulux Prize Finalist (2005)
Work Experience
Teaching commitments
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CHM 1011: Chemistry 1-Practicals
- CHM 1022: Chemistry 1-Practicals
- CHM 3931: Chemistry of Bioactive Compounds - Practicals.
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